Off-the-Shelf Product to Remove Antimicrobial Resistant Bacteria

To develop a platform to create “off-the-shelf” products, the team established the GOTraP™ platform that uses non-replicating phage-based particles rather than bona-fide phages for injecting a desired genetic payload (CRISPR-Cas or growth inhibitors) into desired bacteria. The platform allows production of particles with extended host range. GOTraP™ direct-evolution technology optimizes DNA delivery into specific strains by directed selection.